fn md-rt/ e-koot-n: shes lost control, joy division/ drinking china tee, black/ am carrying out another experiment: dramatically reducing my methadone intake to see how long it takes for real, sustained sickness to set in/ with heroin, one can smoke £100 worth (with a bit of practice) and wake 10 hours later getting or already sick/ the sickness will rapidly become more painful until one is virtually immobilized/ methadone works differently/ it is slower acting thus gifting less of a high and lasting longer/ now it is claimed methadones longevity is slightly more than heroins and that methadone does not, as claimed by many, hole up in the fat, bones andseterah/ i've been taking meth daily for three years, beginning at 110mls, plus healthy use atop, and have managed to get down to about 45mls with very little use on top/ three days ago i decided to drop to 30mls/ since i've experienced no serious symptoms of sickness/ methadones life span cannot be increased, thus there must some stored in the body to explain my lack of symptoms or some other explanation/
Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs. Methadone has a typical elimination half-life of 15 to 60 hours with a mean of around 22. However, metabolism rates vary greatly between individuals, up to a factor of 100,[5][6] ranging from as few as 4 hours to as many as 130 hours,[7] or even 190 hours.[8] This variability is apparently due to genetic variability in the production of the associated enzymes CYP3A4 and CYP2D6. A longer half life frequently allows for administration only once a day in heroin detoxification and maintenance programs. Patients who metabolize methadone rapidly, on the other hand, may require twice daily dosing to obtain sufficient symptom alleviation while avoiding excessive peaks and troughs in their blood concentrations and associated effects.[7] This can also allow lower total doses in some such patients. The analgesic activity is shorter than the pharmacological half-life; dosing for pain control usually requires multiple doses per day.
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